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  Meta-analyses: a global analysis of clinical trials
  Clinical trials with conclusive results

Meta-analyses are rigorous studies that involve scores of clinical trials and aim to assess the quality of the studies that have been carried out and the consistency of the results.

© Artechnique

In less than one decade, the conclusions from meta-analyses involving homeopathy have convinced their authors of the acceptability of homeopathic clinical trials and their positive results.

Trial methods with recognised reliability

In 1991, a meta-analysis was published which involved the meticulous study of 107 trials1 . As regards methods used for the clinical evaluation, the conclusion was clear: “it is wrong to say that homeopathy has not been evaluated according to the modern method of controlled trials”. Among these clinical trials, a large majority (81 to be exact) has had positive results concerning the efficacy of homeopathic treatment.

Ruling out the notions of chance and the placebo effect

A similar study was conducted in 1996 at the European Parliament's request2 . It examined the data from trials involving the efficacy of homeopathic medicines in relation to a placebo or to no treatment. Comparisons were retained satisfying all of the experts' requirements, who finally concluded that “the number of significant results was clearly not down to chance”.

A year later (1997), a study involving the analysis of 89 trials was published3 taking close account of the criteria specific to the homeopathic therapeutic method. It concluded that even if evidence of the complete efficacy of homeopathy in the treatment of a single given patient were insufficient, “it was impossible that the clinical effects of the homeopathy were exclusively caused by a placebo effect”.

In August 2005, the weekly journal The Lancet published a new study4 on the effectiveness of homeopathy. In its editorial the journal drew some surprisingly controversial and unfavourable conclusions on homeopathy. It concerns an analysis which like the 3 previous meta-analyses concludes that homeopathic medicine is effective. However, to arrive at the opposite conclusion, the authors implicitly removed series of trials afterwards, retaining just 14 (8 on homeopathy) of the 220 initial trials (110 of which were on homeopathic medicine). In December 20055, The Lancet printed 4 letters from researches in response to this publication. The conclusions are that: 19% of the homeopathic trials and 8% of the allopathic trials are of the best quality; the 110 trials on homeopathic medicine show a positive treatment effect in relation to a placebo which is absolutely comparable to that shown by the trials on conventional medicines.

These meta-analyses highlight the perfectibility of the research conducted in homeopathy and the necessity of rigorously and systematically pursuing them. But they also show that the reliability of the testing to which homeopathy is already subjected is beyond doubt.

 

More : Meta-analyses: p.11-15
(extract from the book "La recherche en homéopathie", coordination Doctor Philippe Belon, 2004)

 

  Meta-analyses: a global analysis of clinical trials
  Clinical trials with conclusive results

 

 
 
 
 
 
 















From now on it is impossible to associate the results of homeopathic clinical results solely to the placebo effect















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